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Science Advances Archives

New view of mutations informs disease risk, treatment response

May. 18, 2023—A transcontinental research effort led by scientists from Vanderbilt University Medical Center and the University of Michigan has upended some long-standing assumptions about mutations — how often they occur, what causes them and what they do.

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System repairs donor lungs for transplantation

Apr. 6, 2023—A Vanderbilt team has discovered that donor lungs rejected for transplant can be repaired using cross-circulation with a xenogeneic host.

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Aging beta cells hasten Type 2 diabetes

Oct. 20, 2022—Vanderbilt investigators have found that aging induces chronic cellular stress in pancreatic beta cells, which could contribute to the development of diabetes as we age.

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Game theory points to new DNA data privacy solutions

Dec. 16, 2021—Vanderbilt research is blazing a trail for the application of game theory to genomic and health data reidentification risk.

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New clues to lung-scarring disease may aid treatment

Jul. 8, 2020—Scientists at Vanderbilt University Medical Center and the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF).

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Genetic screen in worms reveals critical step in insulin synthesis

Dec. 4, 2019—The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes.

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Clue to treating obesity found in body’s ‘rheostat’

Aug. 23, 2018—Researchers at Vanderbilt University and the University of Michigan have discovered a critical factor in the rheostatic control of body weight by the brain.

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Long QT syndrome – revealed

Mar. 12, 2018—Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.

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Discovery sheds light on protein key to nerve cells’ myelin sheath

Aug. 17, 2017—Genetic mutations in PMP22 (peripheral myelin protein 22) cause a variety of peripheral neuropathies, underscoring the importance of the protein to a healthy peripheral nervous system. But the precise function of PMP22, a major component of the myelin sheath that surrounds and insulates peripheral nerve cell axons, has been unclear.

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Protein structure may aid in treating Alzheimer’s disease

Apr. 27, 2017—A new protein structure may guide the development of Alzheimer's therapeutics.

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Study reveals new clues to cystic fibrosis ‘gender gap’

Sep. 15, 2016—A research team led by structural biologists from Vanderbilt University has come up with the first detailed molecular explanation for a factor that may contribute to the so-called cystic fibrosis (CF) “gender gap.”

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