T cell Archives
Study identifies key player in T cell “education”
Sep. 1, 2022—New Vanderbilt research could inform therapeutic strategies for enhancing thymic function when desired — such as during aging, recovery from radiation therapy or chemotherapy, or other conditions that reduce T cell output.
Blood test figures in cancer risk for people with HIV
Mar. 17, 2022—A Vanderbilt study found that, among adult patients with HIV, those who have lower counts of certain types of blood cells have a markedly higher risk of developing cancer.
Melanoma treatment response
Feb. 24, 2022—Targeting the interaction between melanoma and immune cells could improve responses to targeted cancer therapies, Vanderbilt researchers found.
CRISPR screen identifies new anti-inflammatory drug target
Nov. 11, 2021—A novel CRISPR screen developed by Vanderbilt researchers identified a promising new target for anti-inflammatory therapeutics.
‘Pre-conditioning’ restores immune tolerance
Sep. 16, 2021—A treatment targeting T-cell metabolism could reinvigorate immune tolerance mechanisms to combat autoimmune disease and transplant rejection, Vanderbilt researchers discovered.
Breast cancer cells ‘steal’ nutrients from immune cells: study
Apr. 1, 2021—Triple-negative breast cancer cells engage in a “glutamine steal” — outcompeting T cells for the nutrient glutamine and impairing their ability to kill tumor cells, Vanderbilt researchers have discovered.
HIV, diabetes and immune cells in fat
Mar. 18, 2021—In HIV-positive individuals with diabetes, immune cells in fat are more proinflammatory and cytotoxic and may represent a therapeutic target for diabetes.
Key factors in HIV-1 replication
Feb. 8, 2021—HIV-1, the virus that causes AIDS, exploits inositol phosphates in T cells to aid its own assembly and maturation — suggesting that targeting inositol phosphate binding could inhibit HIV-1 replication.
Study reveals new strategy for reducing tumor growth, metastasis
Dec. 17, 2020—A team of Vanderbilt investigators has discovered that blocking a certain signaling pathway boosts antitumor immunity and reduces tumor growth and metastasis in models of breast cancer and melanoma.
Rational vaccine design
Sep. 22, 2020—Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development.
“Nur” target may aid arthritis treatment
Jul. 13, 2020—Vanderbilt immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells.
Madhur receives Presidential Early Career Award
Jul. 18, 2019—Meena Madhur, MD, PhD, has received a Presidential Early Career Award for Scientists and Engineers.