TGF-beta Archives

Opening a window to glaucoma

Oct. 10, 2022—A metalloprotease enzyme plays an important role in retinal ganglion cell development, Vanderbilt researchers discovered; studying it and other family members may lead to the identification of novel targets for treating glaucoma.

Probiotic protection

Mar. 4, 2021—A probiotic factor given early in life to mice prevented intestinal inflammation in adulthood, providing a rationale for probiotic intervention in individuals at high risk of developing inflammatory bowel disease.

Potential new cancer target

Jun. 4, 2020—Vanderbilt researchers have discovered the involvement of a certain type of adenosine receptor in mediating signaling that supports tumor growth and metastasis.

SMAD4 clue to colon cancer

Jul. 2, 2018—Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.

Symposium honors Moses’ storied cancer research career

Oct. 19, 2017—Members of the Vanderbilt University Medical Center (VUMC) community and others whose lives and careers have been influenced by legendary cancer investigator, educator and administrator Harold (Hal) Moses, M.D., have endowed the Linda and Harold L. Moses, M.D. Career Development Fund.

Colorectal cancer clues

Jan. 19, 2017—Although cancers arising from different areas of the large intestine are heterogeneous, they appear to use similar important tumorigenic pathways.

Surprising finding in the kidney

Apr. 16, 2015—TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling.

Enzyme affects tumor metastasis

Jan. 8, 2015—A protein that degrades the “matrix” between cells participates in the development of lung metastases from primary breast cancer in mouse models and may be a good target for breast cancer treatment.

New insight on oral cancer culprits

Nov. 12, 2014—A new mouse model offers insight into the signaling pathways that control oral cancers – and a platform for testing anticancer therapeutics.

Molecular ‘chat’ holds kidney fibrosis clues

Jul. 10, 2014—A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process.