transporter Archives
Transporter’s role in gut barrier
Apr. 16, 2020—A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections.
Transporter mutation alters cell energy
Feb. 20, 2020—A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.
Blueprint for treating epilepsy
Nov. 14, 2019—Structural details of a protein that is essential to normal brain function could improve treatments for epilepsy and other seizure disorders.
Defective transporter linked to autism
Jul. 24, 2019—A first-of-its-kind mouse model may help reveal mechanistic underpinnings for the altered behaviors of autism spectrum disorder.
Study details regulation of a multi-drug transporter
May. 29, 2019—P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.
A new target for lung cancer
Aug. 16, 2018—Vanderbilt researchers have identified a new vulnerability in lung cancer — the transporter protein xCT — that may a therapeutic target for the disease.
Fueling the MATE transporter
Jul. 19, 2018—Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.
New view of transporter dynamics
Oct. 23, 2014—New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants.
Neuronal culprit in genetic disease
Oct. 14, 2014—A particular neuronal cell population is involved in the pathogenesis of a rare neurological disorder, Vanderbilt researchers have discovered.
New view of neurotransmitter transport
Apr. 24, 2014—Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders.
Neurotransmitter’s role in bone balance
Nov. 7, 2013—Removal of the neurotransmitter norepinephrine from the space outside cells plays an important role in the regulation of bone remodeling.
