Vanderbilt Center for Bone Biology Archives
Signaling pathways in liposarcomas
Jul. 25, 2023—A broad bioinformatics approach revealed that Hedgehog signaling is upregulated in dedifferentiated liposarcoma, suggesting this pathway may be an early indicator of poor prognosis and a potential therapeutic target.
Diagnostic biomarker for bone disorder
Sep. 27, 2022—A urine chemical performs better as a diagnostic biomarker for the soft bone disease hypophosphatasia than other laboratory measures, Vanderbilt researchers have demonstrated.
Nyman named Center for Bone Biology director
Apr. 28, 2022—Jeffry Nyman, PhD, professor of Orthopaedic Surgery and research associate professor of Biomedical Engineering, has been named director of the Vanderbilt Center for Bone Biology.
Bone matrix changes during aging
Jan. 10, 2020—Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis.
Keeping bone in its place
Apr. 11, 2019—Jonathan Schoenecker and colleagues have discovered a new mechanism for the formation of bone in soft tissues — a complication of severe injuries that causes pain and limits mobility.
Clues to bone metastases
Oct. 26, 2018—Vanderbilt researchers are developing new approaches to study the mechanisms underlying why breast cancer cells home to bone and lie dormant, evading treatment.
Stress may switch on bone “mets”
Aug. 9, 2017—New findings could explain the link between chronic stress and reduced survival in women diagnosed with breast cancer, and could lead to new strategies to improve treatment outcomes.
Unal receives Orthopedic Research Society award
Jun. 15, 2017—Mustafa Unal, Ph.D., a postdoctoral research fellow at Vanderbilt University School of Medicine, has been selected by the Orthopedic Research Society to receive its 2017 Alice L. Jee Young Investigator Award for work that potentially will improve the clinical assessment of bone strength and quality.
Diabetes study seeks to identify biomarkers for fracture risk
Oct. 20, 2016—Medical studies have established that people with type 2 diabetes are more susceptible to fractures, but the biological process that weakens their bones is not understood.
Wound-healing scaffolds
Jan. 27, 2016—The elasticity of a scaffold used for healing skin wounds is a key factor in promoting regeneration versus scarring.
VUMC study shifts thinking on how bone fractures heal
Aug. 13, 2015—New findings show that fibrin, a protein that was thought to play a key role in fracture healing, is not required, shifting understanding of how fractures heal.
Targeting bone metastasis
Jul. 23, 2015—The rigidity of the bone extracellular matrix increases the ability of tumor cells to destroy bone, suggesting new targets for anticancer drug development.
