Early steps in reovirus replication
Oct. 6, 2020—Conformational change in a reovirus surface protein modulate the virus’s attachment to host cells, Vanderbilt researchers have found.
Probing innate immunity
May. 19, 2020—Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.
Antibodies eye Pacific Island “fever”
May. 14, 2020—Vanderbilt Vaccine Center team isolates monoclonal antibodies against Ross River virus, which causes rash, fever and debilitating muscle and joint pain lasting three to six months.
RNA processing and antiviral immunity
Dec. 13, 2018—John Karijolich and colleagues have discovered a link between cellular RNA processing and the innate cellular immune response to viral pathogens.
Team explores diabetes drug’s ability to treat RSV infection
Jul. 12, 2018—A drug used to treat diabetes may point to new therapies for respiratory syncytial virus (RSV) bronchiolitis — inflammation and obstruction of the lungs’ small airways. A multi-disciplinary team of Vanderbilt investigators has demonstrated that liraglutide reduces the inflammatory response to RSV infection in a mouse model of the disease.
Karijolich named 2018 Pew Biomedical Scholar
Jun. 14, 2018—John Karijolich, PhD, assistant professor of Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center, has been named a Pew Biomedical Scholar by The Pew Charitable Trusts.
Evolution of a deadly virus
May. 23, 2018—Genomic sequences have revealed that Florida is a major source of a mosquito-borne virus that causes disease in horses and humans.
New target to stop Ebola
May. 21, 2018—A new Vanderbilt study suggests it may be possible to develop antibody therapies or a universal vaccine effective against multiple Ebola virus family members.
Alphavirus “Achilles heel”
May. 17, 2018—Targeting the protein that mosquito-borne viruses use to enter cells could be a strategy for preventing infection by multiple emerging viruses.
Safe to snuggle with pets while home with a cold or flu, Vanderbilt infectious disease expert says
Jan. 13, 2016—When you are home sick, snuggling up with your dog or cat may feel like just what the doctor ordered. And a Vanderbilt infectious disease doctor, while stopping short of actually prescribing in-home “pet therapy” for colds or flu, says that if having your companion by your side makes you feel better, go right ahead....
Enzyme holds the door for influenza
Aug. 20, 2014—Compounds developed at Vanderbilt University may offer a new way to block influenza infection.
Natural killer cells don’t clear HMPV
Jul. 23, 2014—Understanding how the immune system responds to the respiratory virus HMPV is crucial for developing vaccines and anti-viral treatments.