Wnt signaling Archives
Protecting the injured kidney
Jun. 4, 2020—Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.
Clues to lung injury in preterm babies
Mar. 5, 2020—Jennifer Sucre and colleagues have discovered a factor that contributes to the pathological changes of bronchopulmonary dysplasia, the most common complication of preterm birth.
A “rheostat” for cancer signals
Aug. 27, 2019—Jason MacGurn and colleagues have characterized a “rheostat” that sets WNT pathway signaling in breast cancer cells.
Lung diseases share molecular signature
Apr. 5, 2018—Lung diseases of infancy and aging share a molecular signature, pointing to a potential target for treatment and prevention.
Structure of a stem cell niche
Feb. 28, 2018—Understanding the specialized environment where stem cells reside is important for developing stem-cell based regenerative therapies.
A target to heal tiny lungs
Feb. 23, 2017—The protein beta-catenin may be a good target for therapies to treat lung disease that is a common complication of preterm birth.
Colorectal cancer clues
Jan. 19, 2017—Although cancers arising from different areas of the large intestine are heterogeneous, they appear to use similar important tumorigenic pathways.
Wound-healing scaffolds
Jan. 27, 2016—The elasticity of a scaffold used for healing skin wounds is a key factor in promoting regeneration versus scarring.
Healing without scarring
Oct. 16, 2015—Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.
Heart repair factor
Sep. 17, 2015—A signaling factor called Wnt10b is a novel target for optimizing cardiac repair after a heart attack.
Therapeutic target for synovial sarcoma
Nov. 21, 2013—Inhibitors of a signaling pathway that is critical to synovial sarcoma tumorigenesis may be useful treatments for this aggressive cancer.
Fishing for new anti-cancer drugs
Sep. 18, 2013—Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug.