Wnt signaling Archives

Protecting the injured kidney

Jun. 4, 2020—Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.

Clues to lung injury in preterm babies

Mar. 5, 2020—Jennifer Sucre and colleagues have discovered a factor that contributes to the pathological changes of bronchopulmonary dysplasia, the most common complication of preterm birth.

A “rheostat” for cancer signals

Aug. 27, 2019—Jason MacGurn and colleagues have characterized a “rheostat” that sets WNT pathway signaling in breast cancer cells.

Lung diseases share molecular signature

Apr. 5, 2018—Lung diseases of infancy and aging share a molecular signature, pointing to a potential target for treatment and prevention.

Structure of a stem cell niche

Feb. 28, 2018—Understanding the specialized environment where stem cells reside is important for developing stem-cell based regenerative therapies.

A target to heal tiny lungs

Feb. 23, 2017—The protein beta-catenin may be a good target for therapies to treat lung disease that is a common complication of preterm birth.

Colorectal cancer clues

Jan. 19, 2017—Although cancers arising from different areas of the large intestine are heterogeneous, they appear to use similar important tumorigenic pathways.

Wound-healing scaffolds

Jan. 27, 2016—The elasticity of a scaffold used for healing skin wounds is a key factor in promoting regeneration versus scarring.

Healing without scarring

Oct. 16, 2015—Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.

Heart repair factor

Sep. 17, 2015—A signaling factor called Wnt10b is a novel target for optimizing cardiac repair after a heart attack.

Therapeutic target for synovial sarcoma

Nov. 21, 2013—Inhibitors of a signaling pathway that is critical to synovial sarcoma tumorigenesis may be useful treatments for this aggressive cancer.