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Department of Cell and Developmental Biology Archives

Breast cancer-killing RIG

Dec. 13, 2018—A compound that activates a virus-sensing receptor has potent therapeutic effects in a mouse model of breast cancer.

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The exocyst dynamo

Dec. 13, 2018—New methods have revealed details of vesicle trafficking in cells and are applicable to any protein complexes, potentially revolutionizing our understanding of cell dynamics.

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Team seeks to create gene expression map of worm’s nervous system

Dec. 6, 2018—How do you build a brain? What “rules” govern where neurons end up, how they connect to each other, and which functions they perform?

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Analyzing single-cell landscapes

Nov. 29, 2018—Vanderbilt researchers have developed a new tool for quantifying data from single-cell studies.

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McLaughlin, Casagrande honored by the Society for Neuroscience

Nov. 29, 2018—Two Vanderbilt University scientists — BethAnn McLaughlin, PhD, and the late Vivien Casagrande, PhD — have been honored by the Society for Neuroscience for making significant contributions to the advancement of women in science.

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Evading cell death

Nov. 8, 2018—Stress granules that form in response to cellular stress help cancer cells survive and develop resistance to treatment.

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Novel genetic study sheds new light on risk of heart attack

Oct. 11, 2018—Loss of a protein that regulates mitochondrial function can greatly increase the risk of myocardial infarction (heart attack), Vanderbilt scientists reported Oct. 3 in the journal eLife.

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Cancer Moonshot award to help map tumor progression

Sep. 27, 2018—A trans-institutional team of researchers at Vanderbilt University Medical Center and Vanderbilt University has received an $11 million Cancer Moonshot grant to build a single-cell resolution atlas to map out the routes that benign colonic polyps take to progress to colorectal cancer, the third most common cancer among both men and women in the United States.

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How microvilli form

Sep. 13, 2018—A protein called IRTKS helps build the microvilli that form the border of cells in the intestines, explaining why the protein is a frequent target of gut pathogens.

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First Islet Workshop draws international audience

Sep. 13, 2018—More than 200 investigators from across the globe who specialize in islet biology, the study of hormone-producing cell clusters in the pancreas known as islets, recently gathered in Nashville to share knowledge and present the challenges and successes of their work during the first Islet Biology Workshop at Vanderbilt.

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A brain-builder called “Shh”

Aug. 30, 2018—New findings demonstrate a previously unappreciated role of Shh signaling activity in the proliferation of CGNPs — the presumed cell-of-origin for a subset of the malignant pediatric brain tumor medulloblastoma.

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Gould awarded Sutherland Prize for Achievement in Research

Aug. 30, 2018—Vanderbilt University’s most prestigious faculty honor for accomplishments in research, scholarship or creative expression was awarded to Kathleen Gould, PhD, during the Fall Faculty Assembly Aug. 23.

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