Cancer

Katrin Karbstein, PhD

Katrin Karbstein appointed co-leader of Vanderbilt’s Cancer Cell Biology Research Program

There, she will develop and implement program aims, participate in strategic decision making in the cancer center, direct pilot project funding, facilitate interactions amongst cancer center members, and assist in the recruiting activities for the 42-member program with over $11.7M in annual peer-reviewed funding.

Clinical trial for rectal cancer subtype shows promise for less aggressive treatment

The findings were so promising that the clinical trial is being redesigned to investigate whether radiation treatment can also be avoided.

Cathy Eng, MD

International overview of colorectal cancer provides multidisciplinary perspective of clinical advances

The authors hope the report will provide insight on the importance of education, screening and awareness to all health care providers.

(iStock)

Study of messenger RNA regulatory mechanism reveals cancer risk genes

The Vanderbilt study used RNA-sequencing data generated in multiple normal tissues, along with matched genotype data from the Genotype-Tissue Expression Project as well as large-scale genomic data for cancers of the breast, ovary, prostate, colorectum, lung and pancreas.

Obesity-cancer connection discovery suggests strategies for improving immunotherapy 

The study reported in the journal Nature provides a mechanistic explanation for the “obesity paradox” — that obesity can contribute to cancer progression but also improve response to immunotherapy.

Brooke Emerling, PhD, and Raymond Blind, PhD (seated, in foreground) at a 2023 scientific symposium they organized. Standing next to Blind is Hua Ya, PhD, from the City of Hope Comprehensive Cancer Center. Behind him in the light blue shirt is Emilio Hirsch, PhD, from the University of Torino, Italy.

Discovery raises hopes for new cancer therapy

The study connected the Hippo signaling pathway to phosphoinositides, a particular type of lipid, or fat molecule, which regulates cell functions that are critical in cancer, obesity and diabetes.

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