Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.

Blocking thromboxane-prostanoid receptor signaling protected animals from lung fibrosis in preclinical models, suggesting a new treatment for IPF — a chronic, progressive lung disorder that often kills within 3-5 years of diagnosis.

Sara Horst, MD, MPH, has been named associate vice chair for Digital Health Operations for Vanderbilt's Department of Medicine and assistant chief for Clinical Informatics for the Division of Gastroenterology, Hepatology and Nutrition.

A Vanderbilt study found that reducing dietary carbohydrates improved both symptoms and objective measurements of gastroesophageal reflux disease (GERD) in a randomized controlled trial.

Vanderbilt reseach shows that resources for lung cancer screening programs increased the number of veterans screened.

A urine chemical performs better as a diagnostic biomarker for the soft bone disease hypophosphatasia than other laboratory measures, Vanderbilt researchers have demonstrated.