Aliquots - Research Briefs

brain and lightning

Astrocytes and epilepsy

A protein with important functions in astrocytes — star-shaped brain support cells — may alter neuronal excitability and contribute to seizure activity, Vanderbilt researchers report.

How salt increases blood pressure

Vanderbilt researchers have discovered that a protein called SGK1 in immune cells is activated by sodium, leading to the development of salt-sensitive hypertension.

The plus and minus of microtubules

Understanding the dynamic regulation of cytoskeletal microtubules may suggest new ways to treat disorders ranging from Alzheimer’s disease to cancer.

A “rheostat” for cancer signals

Jason MacGurn and colleagues have characterized a “rheostat” that sets WNT pathway signaling in breast cancer cells.

Cancer susceptibility genes

Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.

How nerves may lose their insulation

Vanderbilt’s Bruce Carter and colleagues have discovered how genetic changes in the protein PMP22 may contribute to a disease of peripheral nerves.

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