Health and Medicine

August 16, 2018

A new target for lung cancer

Vanderbilt researchers have identified a new vulnerability in lung cancer — the transporter protein xCT — that may a therapeutic target for the disease.

By Leigh MacMillan
August 16, 2018

YAP after acute kidney injury

Activation of the signaling protein YAP may be a target for treating acute kidney injury, which affects up to 20 percent of hospitalized patients.

By Sanjay Mishra
August 16, 2018

Predictive models for gene regulation

Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.

By Bill Snyder
August 2, 2018

Repairs in the basement membrane

Studies in fruit flies have shed light on how the basement membrane — a sheet-like scaffold that wraps around most animal tissues — is repaired after being damaged.

By Sanjay Mishra
August 2, 2018

Genetic balancing act

New findings about proteins involved in DNA repair are important for understanding why some cancers are more or less resistant to certain therapies.

By Meredith Jackson
August 2, 2018

How asters form

New findings shed light on the formation of microtubule structures that support cellular processes ranging from cell division to intracellular transport.

By VUMC News and Communications
August 2, 2018

Connecting an asthma gene to leukemia

A receptor previously implicated in asthma may also play roles in other allergic diseases and in leukemia, Vanderbilt researchers have discovered.
By Leigh MacMillan
July 19, 2018

Post-surgical complications

One out of five deaths within 30 days of surgery are associated with a complication, suggesting that prevention and better treatment of common complications will improve postoperative mortality rates.
By Leigh MacMillan
July 19, 2018

Novel insights on “leaky” gut

A protein involved in binding cells together helps maintain the integrity of the intestinal mucosa and plays a protective role in ulcerative colitis.
By Niyati Vachharajani
July 19, 2018

New player in DNA damage repair

New findings open opportunities to understand mechanisms of DNA repair for a toxic form of DNA damage.
By Leigh MacMillan
July 19, 2018

Fueling the MATE transporter

Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.
By Sanjay Mishra
July 2, 2018

SMAD4 clue to colon cancer

Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.
By Bill Snyder
July 2, 2018

Mother knows best

The first demonstration of bacterial DNA in mammalian fetal intestinal tissue suggests that the mother’s microbiome moves into the fetal intestine.
By Leigh MacMillan
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