amyloid

May 22, 2023

Neurofluid flow and Alzheimer’s disease

Vanderbilt researchers used novel MRI methods to noninvasively quantify measures of neurofluid circulation and found that hypertrophy of a site of cerebrospinal fluid egress may be related to amyloid-beta retention in Alzheimer’s disease.

By Leigh MacMillan
May 9, 2023

Neural networks probe proteins

A machine learning method based on neural networks outperformed a mutational scanning model at identifying disease-causing mutations in an Alzheimer’s disease protein, suggesting the method could be useful for facilitating therapeutic design.

By Leigh MacMillan
October 3, 2022

Minority patients less likely to have amyloid plaques necessary for Alzheimer’s treatments

Fewer Black, Hispanic and Asian patients meet biomarker qualifications for landmark treatments that may slow the progression of Alzheimer’s disease by targeting amyloid plaques, according to new findings published in JAMA Neurology.

By Holly Fletcher
April 11, 2022

Peptides promote AFib arrhythmia

Peptide oligomers have detrimental metabolic effects and cause pro-arrhythmic electrophysiological changes in heart atria, suggesting they may contribute to atrial fibrillation.

By Leigh MacMillan
April 5, 2018

Patient’s efforts help shine light on plasma cell disorder

Charlotte Haffner, Vanderbilt’s first patient to undergo a heart transplant followed by a stem cell transplant to treat a plasma cell disorder called primary AL amyloidosis, now she dedicates her time to raising awareness about the rare disease.

By Jessica Pasley
March 27, 2018

Alzheimer’s proteins in ICU survivors

The cognitive impairment that affects patients who survive a stay in the ICU does not appear to have a similar mechanism to Alzheimer’s disease, Vanderbilt researchers have discovered.

By Meredith Jackson
December 1, 2017

Vitamin C deficiency and mitochondrial dysfunction in Alzheimer’s disease

Recent findings suggest that vitamin C deficiency could contribute to Alzheimer’s disease, suggesting that avoiding deficiency through diet and supplementation could protect against disease onset.
By VUMC News and Communications
April 27, 2017

Protein structure may aid in treating Alzheimer’s disease

A new protein structure may guide the development of Alzheimer's therapeutics.
By Leigh MacMillan
December 6, 2012

Multidisciplinary team takes on rare plasma cell disorder

The Vanderbilt Amyloid Multidisciplinary Program (VAMP) is a new approach to treating a rare and misunderstood disease that can kill its victims before they understand what they have been diagnosed with.
By Kathy Whitney