A team at Vanderbilt University Medical Center used machine learning to predict the likelihood of next-day brain function status changes in critical care patients.
High levels of blood markers for vascular endothelial dysfunction were associated with longer periods of confusion in ICU patients, Vanderbilt researchers have discovered.
Dysfunction of the endothelial cells that line blood vessels may contribute to delirium and coma in critically ill patients – and could be a target for therapy.
Study suggests that the “kynurenine” biochemical pathway could be a target for reducing delirium and coma in critically ill patients.
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