Vanderbilt investigators have discovered that a sirtuin protein has oncogenic properties in neuroblastoma cells — and that blocking it reduces their growth and tumor-like characteristics.
An inhibitor of cell metabolism may be a good therapeutic target for neuroblastoma, which accounts for about 15 percent of pediatric cancer-related deaths.
The sphere-forming frequency of neuroblastoma cells is a measure of their proliferative capacity and could help guide treatment strategies for neuroblastoma.
Vanderbilt researchers are exploring how neuroblastoma tumors begin and progress, knowledge that could provide new treatments for this pediatric cancer.
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