topoisomerase

October 21, 2019

Completing DNA synthesis

James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis.

By Leigh MacMillan
March 14, 2019

Correctly copying DNA

A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

By Sanjay Mishra
September 29, 2017

Novel insights to antibiotic targets

New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.

By Leigh MacMillan
Indian mother and child
February 11, 2016

Slight chemical change may improve TB treatments: study

One small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis, Vanderbilt researchers have discovered.

By Leigh MacMillan
July 27, 2015

Anticancer olive compounds

Compounds found in olives and olive oil have anticancer activity, which may contribute to the cancer preventive properties attributed to the Mediterranean diet.

By Leigh MacMillan
February 25, 2015

Antibiotics with anticancer potential

A series of experimental antibiotics may be a good starting point for developing new anticancer drugs.

By Leigh MacMillan
March 2, 2012

‘Detangler’ binds, bends and cuts DNA

New details on the DNA-cutting activity of topoisomerase II, a target of anti-cancer drugs, could lead to better chemotherapeutic agents.
By Leigh MacMillan