diabetes

kidney x-ray

VU study shows common diabetes drug can slow chronic kidney disease progression

Vanderbilt investigators have demonstrated in two studies that metformin-based treatments delay the onset and progression of chronic kidney disease (CKD) compared with other treatments for diabetes.

Insulin in vials

Study tracks insulin’s risks as second-line diabetes medication

In an observational study by researchers at Vanderbilt University Medical Center, adults with type 2 diabetes who take insulin in addition to the recommended first-line drug therapy, metformin, had a 30 percent higher risk of heart attack, stroke or death when compared to similar patients who instead augment their metformin regimen with a sulfonylurea.

Insulin in vials

CaMKII enhances insulin secretion

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion.

Insulin in vials

Matrix remodeling and insulin resistance

The extracellular matrix that surrounds cells plays a role in the development of insulin resistance.

Diabetes study offers medication adherence options

Knowing when to take a medication — and what to do if a dose is missed — could greatly improve adherence to diabetes medications and glycemic control among adults with type 2 diabetes, according to a Vanderbilt study published in the journal Diabetes Care.

Diabetes researchers track cells’ ability to regenerate

Vanderbilt University scientists have found evidence that the insulin-secreting beta cells of the pancreas, which are either killed or become dysfunctional in the two main forms of diabetes, have the capacity to regenerate.

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