Jonathan Schoenecker

From left, J.Court Reese, Stephanie Moore-Lotridge, PhD, Breanne Gibson, PhD, and Jonathan Schoenecker, MD, PhD, are discovering ways to prevent adverse outcomes in orthopaedic surgery.
January 19, 2022

Study identifies molecular trigger of severe injury-induced inflammatory response

Vanderbilt researchers have discovered that early inappropriate activation of the enzyme plasmin caused by severe injury is a trigger of systemic inflammatory response syndrome and resulting organ failure.

By Leigh MacMillan
February 23, 2021

Calcification after severe injury

Vanderbilt researchers have linked bone-related complications of severely injured patients — findings that could help minimize these complications.

By Emily Stembridge
April 11, 2019

Keeping bone in its place

Jonathan Schoenecker and colleagues have discovered a new mechanism for the formation of bone in soft tissues — a complication of severe injuries that causes pain and limits mobility.

By Anivarya Kumar
May 31, 2018

Pediatric and adult orthopaedic surgeons bridge age gap on hip preservation

Tristan Miranda spent the waning days of summer last year on a California beach doing hip pivots on a surfboard — an extraordinary feat for someone who underwent hip surgery just three months earlier.

By Tom Wilemon
window in the process of freezing over
December 8, 2016

Plasmin prevents muscle ‘hardening’ after injury: study

Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries.

By Leigh MacMillan
microscope
December 28, 2015

The most popular research stories of 2015

With discoveries ranging from the origins of consciousness to the end of the universe, 2015 was a year of incredibly diverse research at Vanderbilt University.

By VUMC News and Communications
August 13, 2015

VUMC study shifts thinking on how bone fractures heal

New findings show that fibrin, a protein that was thought to play a key role in fracture healing, is not required, shifting understanding of how fractures heal.
By Leigh MacMillan
April 17, 2015

Stuffed animals bring bacteria to OR

Stuffed animals that pediatric patients bring to the operating room are a reservoir of bacteria that can be effectively sterilized in a household washer/dryer the day before surgery.
By Leigh MacMillan
September 3, 2014

Aggressive bone cancers build more blood vessels

A subpopulation of bone cancer cells may be responsible for driving clinically aggressive behavior, suggesting new treatment options.
By Katherine Venmar