obesity

September 8, 2022

Immune cells drive beta cell loss in Type 2 diabetes

Vanderbilt researchers have discovered details of pancreatic beta cell loss — and potential therapeutic targets — during conditions of overnutrition, as occurs in obesity.

By Kelsey Pinckard
August 25, 2022

Inflammatory driver of obesity

Blocking the EGF receptor signaling pathway in immune system macrophages represents a new target for improving insulin resistance in people with obesity.

By Sarah E. Glass
From left, Raymond C. Harris, MD, Shirong Cao, MD, PhD, Ming-Zhi Zhang, MD, MSc, and colleagues are studying the role of inflammation in obesity.
May 12, 2022

Study sheds light on the dark side of obesity

Vanderbilt research that promotes the anti-inflammatory pathway in macrophages could also reduce some of the bad side effects of obesity.

By Bill Snyder
March 24, 2022

Reducing obesity-related inflammation

A treatment that increases levels of lipid signaling molecules reduced adipose tissue inflammation in obese adults, suggesting this pathway may be a valuable target for modulating fat and systemic inflammation.

By VUMC News and Communications
February 10, 2022

New insights into hypothalamic obesity

A common Type 2 diabetes treatment being tested for hypothalamic obesity had unexpected results on weight loss and total energy expenditure, Vanderbilt researchers report.

By VUMC News and Communications
September 7, 2021

Regulators of fat cell metabolism

Vanderbilt researchers have discovered new details of the regulation of fat cell metabolism, findings that are important for combating obesity.

By Leigh MacMillan
August 26, 2021

Obese children, young adults at higher risk for thyroid cancer

Children and young adults who are obese are at greater risk for malignant thyroid nodules, according to new study from Monroe Carell Jr. Children’s Hospital at Vanderbilt.
By Christina Echegaray
August 12, 2021

Study reveals missing link between high-fat diet, microbiota and heart disease

A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities — and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.
By Leigh MacMillan
November 18, 2020

V Scholar Award to support Byndloss’ cancer research

Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology, has received a V Scholar Award to support her studies of the links between obesity, the gut microbiome and colorectal cancer.
By Leigh MacMillan
November 3, 2020

New treatment for a rare obesity

Diabetes drugs known as GLP-1 receptor agonists, such as exenatide (Byetta), are a promising and safe treatment for a rare form of obesity.
By Bill Snyder
July 14, 2020

New tools to study bioactive lipids

Vanderbilt researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction.
By Leigh MacMillan
March 5, 2020

Biomarker in saliva predicts childhood obesity risk: study

A molecular marker in saliva is associated with the emergence of childhood obesity in a group of preschool-aged Hispanic children.
By Leigh MacMillan
January 9, 2020

Impact of weight gain from early to middle adulthood explored

An analysis of weight gain occurring from early to middle adulthood indicates that the added weight is associated with multiple health outcomes in later life.
By Tom Wilemon
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