sepsis

3d rendering white blood cells with red blood cells
May 9, 2018

Putting the brakes on sepsis

An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.

By Leigh MacMillan
February 15, 2018

Sepsis trial ranked No. 1 on critical care website

A clinical trial of an intervention for sepsis in patients in Zambia, led by Vanderbilt investigators, topped the list of 2017 trials featured by the website The Bottom Line.

By Leigh MacMillan
storming night with many bolts of lightning
June 22, 2017

VU scientists report a way to calm the sepsis “storm”

Researchers at Vanderbilt University Medical Center (VUMC) have found a way to calm the “genomic storm” that triggers the often-lethal consequences of sepsis.

By Bill Snyder
February 8, 2017

Pathology of septic shock

The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.

By Leigh MacMillan
June 2, 2016

VUMC researchers seek to crack the code of neonatal sepsis

Sepsis, an exaggerated and overwhelming inflammatory response to infection, is a major worldwide killer of babies in the first four weeks of life (neonatal period).

By Bill Snyder
blood cells
January 7, 2016

Immune tolerance in endothelial cells

Inducing “tolerance” to bacterial toxins in the endothelial cells that line blood vessels may offer a new approach for preventing the negative consequences of sepsis.

By Leigh MacMillan
October 15, 2014

Antibiotics, fetal vessel defect linked

Certain antibiotics increase the risk of a congenital heart disorder called patency of the ductus arteriosis.
By VUMC News and Communications
March 28, 2013

Acetaminophen: protective in sepsis?

In critically ill patients with sepsis, plasma hemoglobin may be a new indicator of disease severity – and a potential target for treatment with acetaminophen.
By Leigh MacMillan