Xingyi Guo

December 3, 2025

Large-scale integration of genomics, proteomics and clinical records identifies cancer risk proteins and potential therapeutics

A new study identifies previously unreported protein biomarkers and candidate drug targets across six major cancer types and highlights approved drugs with potential cancer preventive effects.

By Leigh MacMillan
October 15, 2025

New NCI-funded project targets polyp recurrence to prevent colon cancer

The researchers anticipate that their findings will inform personalized colorectal polyp surveillance, guide therapeutic prevention strategies, and ultimately reduce the burden of colorectal cancer nationwide.

By Leigh MacMillan
November 26, 2024

Novel genetics approach enhances discovery of disease risk genes

VUMC researchers applied the new approach to large GWAS datasets for breast, prostate and lung cancers, and three brain disorders.

By Leigh MacMillan
(iStock)
June 19, 2024

Study of messenger RNA regulatory mechanism reveals cancer risk genes

The Vanderbilt study used RNA-sequencing data generated in multiple normal tissues, along with matched genotype data from the Genotype-Tissue Expression Project as well as large-scale genomic data for cancers of the breast, ovary, prostate, colorectum, lung and pancreas.

By Tom Wilemon
September 12, 2023

Study finds new genetic susceptibilities for colon cancer

Vanderbilt researchers at have found new genes that put people at higher risk for colon cancer and rectal cancer. 

By Tom Wilemon
January 5, 2023

New approach outperforms existing cancer susceptibility models

A new approach for conducting gene-based analyses for cancer susceptibility created at Vanderbilt outperforms existing models.

By Tom Wilemon
September 30, 2021

Study shows how a protein coding gene confers breast cancer susceptibility during DNA transcription

Vanderbilt-Ingram Cancer Center research is providing new insights into how genetic variants convey breast cancer susceptibility by altering the transcription factor proteins that convert DNA strands into RNA.
By Tom Wilemon
October 29, 2020

New markers of colorectal cancer risk

Vanderbilt epidemiologists identified new markers for colorectal cancer risk and characterized a previously unidentified tumor suppressor that regulates overall tumor volume in vivo.
By Sarah E. Glass
September 7, 2020

Possible key to COVID-19 infectivity

New findings demonstrate how genetic variations in the receptor that binds SARS-CoV-2 impact virus recognition and infectivity and offer insights to COVID-19 susceptibility and treatment.
By Sarah E. Glass
August 26, 2019

Cancer susceptibility genes

Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.
By Leigh MacMillan
May 4, 2018

New breast cancer targets

A special genetic analysis has revealed candidate genes associated with increased risk of breast cancer.
By Bill Snyder