Aliquots - Research Briefs

doctor checking patient's blood pressure
January 12, 2021

Mitochondrial stress and hypertension

Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential.

By Leigh MacMillan
January 11, 2021

Microbial RNA and rheumatoid arthritis

Small RNAs — short stretches of genetic material — from microbes may be playing a role in rheumatoid arthritis and other autoimmune diseases.

By Leigh MacMillan
January 7, 2021

Vitamin D activation and cancer risk

Vitamin D protection against colon cancer varies according to parathyroid hormone response, particularly among women.

By Paul Govern
January 7, 2021

Building a cohort, the easy way

An automated system using keyword searches can help identify candidates for clinical trials on adverse drug reactions.

By Paul Govern
December 15, 2020

A deeper look at out-of-home care

Geographically targeted efforts to prevent children being placed in out-of-home care might be possible, Vanderbilt researchers report.

By Bill Snyder
December 14, 2020

Polymer protection for heart muscle

Vanderbilt researchers demonstrate that the polymer P188 has promise as a therapy to prevent reperfusion injury — the cellular damage that occurs when blood flow returns after an ischemic event like a heart attack.

By Leigh MacMillan
December 10, 2020

Model students: improving clinical decision-making

Vanderbilt investigators have devised a system to alert health IT teams to deteriorating performance in clinical prediction models.
By Paul Govern
December 10, 2020

Exploiting viral vulnerabilities

The isolation of human monoclonal antibodies against dangerous viruses including EEEV, Hendra and Nipah could offer new ways to treat and prevent these infections.
By Bill Snyder
November 17, 2020

A cohort for type 2 diabetes studies

A study group of more than 600,000 patients with type 2 diabetes, identified from electronic medical records in the PCORnet national research network, could be valuable for assessing the safety of type 2 diabetes drugs.
By Leigh MacMillan
November 16, 2020

Imaging “biomarker” for Alzheimer’s disease progression

Changes in connectivity in the brain’s white matter may be a novel neuroimaging biomarker for assessing Alzheimer’s disease progression.
By Bill Snyder
November 12, 2020

New therapeutic target for lung cancer

Vanderbilt researchers have identified a new molecular partner — and potential therapeutic target — in a signaling axis that drives lung cancer.
By Sarah E. Glass
November 12, 2020

Breast cancer treatment in older women

A new study from Vanderbilt epidemiologists suggests that it’s time to reconsider clinical practice guidelines for the treatment of early-stage breast cancer in older women.
By Leigh MacMillan
November 3, 2020

New treatment for a rare obesity

Diabetes drugs known as GLP-1 receptor agonists, such as exenatide (Byetta), are a promising and safe treatment for a rare form of obesity.
By Bill Snyder
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