Aliquots - Research Briefs

March 24, 2020

Spasticity underdiagnosed

Spasticity — a consequence of stroke and other disorders of the central nervous system — may be underdiagnosed and undertreated in nursing home residents.

By Paul Govern
March 23, 2020

Cellular factor helps package flu genome

New insights on influenza genome packaging could guide strategies for interfering with the virus’s life cycle and ability to cause infection.

By Leigh MacMillan
March 19, 2020

Race, hormones and diabetes risk

Variation in the levels of hormones called natriuretic peptides may contribute to racial differences in susceptibility to diabetes, suggesting that this hormone system may be a target for reducing risk of the disease.

By VUMC News and Communications
March 19, 2020

Blocking stress-induced relapse

Danny Winder and colleagues are teasing apart the actions of neurotransmitter receptors in a brain region linked to anxiety and addiction, with a goal of finding treatments for substance use disorders.

By Bill Snyder
March 10, 2020

Loss of ‘Jedi’ alters neuron activity

This is not the Jedi you’re thinking of. This Jedi is a receptor that helps clear away dead neurons during development, and its loss changes the activity of dorsal root ganglia neurons, which could have implications for treating chronic pain.

By Leigh MacMillan
March 9, 2020

Meat intake and colorectal polyps

Red and processed meat intakes are strongly associated with increased risk of sessile serrated polyps, which are not as well studied as conventional adenomas.

By Leigh MacMillan
March 5, 2020

Clues to lung injury in preterm babies

Jennifer Sucre and colleagues have discovered a factor that contributes to the pathological changes of bronchopulmonary dysplasia, the most common complication of preterm birth.
By Leigh MacMillan
March 5, 2020

One-two punch for cancer

A drug combination effectively killed aggressive blood cancers in cell and animal models; now it’s being tested in patients.
By Sanjay Mishra
February 25, 2020

Looking through MudPIT for protein interactions

The identification of novel protein interactions and sites of modification in proteins involved in mRNA translation adds to understanding of a process that is an important therapeutic target.
By Sanjay Mishra
February 24, 2020

Reducing postoperative opioids

An opioid-restrictive prescribing protocol reduced the number of postoperative opioid prescriptions and the oral morphine equivalent per prescription.
By Leigh MacMillan
February 20, 2020

Protein interactions and brain function

Roger Colbran and colleagues have discovered new molecular details about the function of an enzyme with a key role in shaping learning and memory.
By Bill Snyder
February 20, 2020

Transporter mutation alters cell energy

A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.
By Leigh MacMillan
February 11, 2020

A key to calcium signaling

Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.
By Sanjay Mishra
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