antidepressants

July 11, 2022

A speedier treatment for depression?

Vanderbilt researchers used a computer-based search to identify a compound with promise as a new, mechanistically distinct and rapid-acting therapy for major depressive disorder.

By Paul Govern
Research by Dane Chetkovich, MD, PhD, right, Ye Han, PhD, and colleagues on how antidepressants work points to possible new targets for drug development.
December 1, 2021

Study provides new insight into how antidepressant drugs work

A study by Vanderbilt researchers sheds light on how current antidepressant drugs work and suggests a new drug target in depression.

By Paul Govern
Max Joffe, PhD, left, P. Jeffrey Conn, PhD, and colleagues are studying a new class of antidepressants that may relieve symptoms more rapidly and with fewer side effects.
November 21, 2019

Study explores potential new class of antidepressants

Researchers at VUMC have taken a major step that could ultimately facilitate development of a new class of antidepressants which may relieve symptoms more rapidly and effectively and with fewer side effects than current medications.

By Bill Snyder
July 25, 2019

Study ‘ignites’ link between genes and drug response

A national study is seeking to determine whether genetic testing can help physicians choose the best drugs for their patients to relieve pain and depression.

By Bill Snyder
November 23, 2016

Reducing antidepressants’ side effects

Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk.

By VUMC News and Communications
October 13, 2016

Antidepressants’ heart impact less than expected: study

A Vanderbilt University study published today in the Journal of Clinical Psychiatry may help patients prescribed higher doses of certain antidepressants feel better about attributed cardiac risks.

By Paul Govern
August 3, 2016

Fetal impact of antidepressants

Antidepressant use during pregnancy is common. Fetal exposure to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) is associated with the life-threatening condition PPHN (persistent pulmonary hypertension of the newborn), but a causal link has not been established.
By Leigh MacMillan
April 24, 2014

New view of neurotransmitter transport

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders.
By Leigh MacMillan
January 7, 2014

Vanderbilt study shows suicide risk doesn’t differ in children taking two types of commonly prescribed antidepressants

A new Vanderbilt University Medical Center study shows there is no evidence that the risk of suicide differs with two commonly prescribed antidepressants prescribed to children and adolescents.
By Nancy Humphrey