Basic Sciences

A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.

Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.

Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation.

Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.

A drug that targets multiple pathogenic steps in diabetic retinopathy may be an ideal therapeutic strategy for the disease, Vanderbilt researchers report.

An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms.

D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.