brain development

Team seeks to create gene expression map of worm’s nervous system

How do you build a brain? What “rules” govern where neurons end up, how they connect to each other, and which functions they perform?

A brain-builder called “Shh”

New findings demonstrate a previously unappreciated role of Shh signaling activity in the proliferation of CGNPs — the presumed cell-of-origin for a subset of the malignant pediatric brain tumor medulloblastoma.