DNA damage

April 15, 2016

Mechanism of a DNA repair protein

Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

By Sanjay Mishra
January 8, 2016

Copying chromosome caps

Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.

By Leigh MacMillan
DNA sequence visualization
July 16, 2015

Study reveals how protein helps cells tolerate DNA damage

Vanderbilt and Stanford investigators have discovered how a protein that’s part of the DNA replication “machinery” helps cells tolerate DNA damage.

By Leigh MacMillan
May 23, 2014

Repair protein’s DNA recognition motif

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

By Leigh MacMillan
May 9, 2014

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

By VUMC News and Communications
July 17, 2013

Probing roles of a cell death protein

Vanderbilt researchers have discovered new roles for a protein involved in cell death processes that are activated to prevent tumor-causing DNA mutations.

By Leigh MacMillan
December 24, 2012

A drug combo for ovarian cancer

Combining another drug with platinum-based chemotherapies may be more effective against ovarian cancer.
By Leigh MacMillan
November 21, 2012

Carcinogenic chemicals cramp DNA

Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.
By VUMC News and Communications
October 25, 2012

Bid protein guards blood cells against stress

A protein normally known to promote cell death found to encourage survival of blood forming cells.
By VUMC News and Communications
June 22, 2012

Kids’ cells okay after mom’s cancer radiation

Study finds no evidence of increased mitochondrial mutations in the children of women treated with radiation for cancer.
By VUMC News and Communications
June 8, 2012

DNA: From modification to mutation

Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation.
By Leigh MacMillan
March 19, 2012

iPOND method goes fishing for proteins

A new tool will allow researchers to identify proteins involved in DNA replication and damage repair, processes that go awry in cancer.
By Leigh MacMillan
January 25, 2012

Protein repairs esophageal DNA damage

A protein involved in repairing DNA damage associated with gastric reflux may play a tumor suppressor role in the esophagus and could represent a target for therapies to combat esophageal cancer.
By VUMC News and Communications