F Guengerich

June 12, 2019

Steroid binding to metabolic enzyme

Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.

By Bill Snyder

July 25, 2017

Altered metabolism and disease

Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

By VUMC News and Communications

January 22, 2016

Faulty building blocks in DNA

An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

By Bill Snyder

October 7, 2015

Rational design of novel antifungals

Structural and molecular details of an anti-fungal target’s interaction with inhibitors suggest ways to design better treatments for fungal infections.

By VUMC News and Communications

August 25, 2015

How the cell makes morphine

Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine.

By Sanjay Mishra

May 9, 2014

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.