G protein-coupled receptors Archive — Page 1 of 1

From left, Sheila Collins, PhD, Ryan Ceddia, PhD, and Heidi Hamm, PhD, and their colleagues have identified a potential new approach to reducing the global impact of obesity and diabetes. (photo by Erin O. Smith)
September 6, 2023

Releasing a brake that drives obesity and diabetes

Vanderbilt researchers have uncovered a potential new way to help curb the rapidly rising worldwide prevalence of metabolic disorders, including obesity and diabetes.

By Bill Snyder
December 17, 2019

Cell fate signaling

A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.

By Leigh MacMillan
April 11, 2019

The arrestin-GPCR connection

Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular “inboxes” that are targeted by up to half of all pharmaceuticals.

By Sanjay Mishra
January 23, 2015

New view of dopamine heteromers

Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist.

By VUMC News and Communications
(iStockphoto)
December 2, 2013

VU researchers report G protein advancement that could lead to more effective drugs

Thanks in part to a computer program named “Rosetta,” Vanderbilt University researchers are closer to understanding how the ubiquitous G protein is activated – a discovery that could lead to the design of more specific and effective drugs.

By Bill Snyder
January 18, 2013

Seeing light receptor’s interactions

Understanding how the main receptor for light interacts with other signaling molecules may inform new pharmaceutical development.

By Leigh MacMillan