gastrointestinal disorders

November 7, 2022

Gene mutations impair gut barrier

Mutations in a cell membrane transporter protein impair the integrity of the gut lining, contributing to chronic gastrointestinal distress for people with the mutations, Vanderbilt researchers report.

By Kelsey Pinckard
August 5, 2021

Motor protein linked to intestinal cell differentiation

The motor protein MYO5B, a cause of the congenital intestinal disorder microvillus inclusion disease, does more than move cellular cargo, Vanderbilt researchers have discovered.

By Sarah E. Glass
April 16, 2020

Transporter’s role in gut barrier

A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections.

By Leigh MacMillan
x-ray of stomach
December 4, 2018

Study defines association of oral anticoagulants and proton pump inhibitors to gastrointestinal bleeding risk

A Vanderbilt University Medical Center study published this week in JAMA shows that patients already at higher risk for gastrointestinal bleeding gain a marked protection from this risk when they take a proton pump inhibitor (PPI) in combination with an oral anticoagulant.

By Jill Clendening
child sick to his stomach
April 28, 2016

Study sheds light on link between autism, GI issues

Researchers at Columbia and Vanderbilt universities have made an important discovery in mice that has implications for understanding the gastrointestinal (GI) problems experienced by some children with autism.

By Bill Snyder
Illustration of human intestinal tract
July 30, 2015

Study sheds light on human gut’s ‘pacemaker’ cells

The gut has its own built-in pacemakers, populations of specialized cells that control smooth muscle contraction in the stomach, small intestine and colon.

By Bill Snyder
July 24, 2014

Team spots trigger for rare diarrheal disease in infants

Researchers at Vanderbilt University, the University of Arizona and Phoenix Children’s Hospital have discovered what triggers a rare but devastating diarrheal disease in newborns that is fatal without intravenous feeding or intestinal transplant.
By Bill Snyder