genetic disorder Archive — Page 1 of 1

Stylized close-up of dark molecular ball-and-stick structures against a bright blue-white background.
June 27, 2023

Rare disorder sheds light on dysbindin function

A case study of a rare disorder uncovers roles for the protein dysbindin in the adaptive immune response and suggests that mutations may underlie some cases of very early onset inflammatory bowel disease.

By Sarah E. Glass
Abstract ceramic mosaic of interlocking puzzle-like shapes made from small tiles in yellow, blue, orange, white, gray, purple, and black.
June 22, 2023

Mosaicism and genetic disease

Genetic mosaicism — when the body’s cells do not all have the same genetic makeup — could generate variants previously thought to be spontaneous in genetic disease, and detecting parental mosaicism could clarify recurrence risk for future children.

By Leigh MacMillan
Close-up 3D rendering of densely packed pink, rounded finger-like biological structures, with larger forms in the foreground and smaller ones receding into the background.
February 2, 2023

Nutrient absorption disease model

Vanderbilt researchers developed a model of a patient-specific mutation to explore the pathology of microvillus inclusion disease, a genetic disorder that causes life-threatening diarrhea.

By Leigh MacMillan
Five healthcare professionals pose outdoors in front of a building; three wear white coats, one wears a patterned blouse, and one wears blue medical scrubs.
June 3, 2021

VUMC team discovers new genetic disease

Researchers at Vanderbilt University Medical Center have discovered a new genetic disease that causes a severe form of neurogenic orthostatic hypotension, a rapid drop in blood pressure upon standing that can cause fainting.

By Bill Snyder
May 20, 2021

New clue to lung scarring

Vanderbilt neonatology team pinpoints signaling pathways involved in the progressive lung fibrosis that occurs in rare genetic diseases.

By Bill Snyder
June 6, 2019

Treating core Rett syndrome symptoms

A new study published in Neurology reports the drug trofinetide has proven safe and effective in treating core symptoms of Rett syndrome in female children and adolescents.

By Kelsey Herbers