heart rhythm

May 19, 2022

A clue to an adverse drug event in children

Considering metabolic (CYP2D6) enzyme activity score and patient age may aid in determining an individual’s risk for an adverse event with administration of the anti-arrhythmic drug propafenone.

By Joshua Baker
April 15, 2021

Arrhythmia culprit: supertrafficking ion channel

Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities.

By Leigh MacMillan
June 12, 2020

Robotic technology speeds arrhythmia gene classification

Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions.

By Leigh MacMillan
April 6, 2018

New view of the heartbeat

Structural views of the proteins that regulate the heartbeat may help improve existing treatments for cardiac arrhythmias.

By Sanjay Mishra
ekg results
March 12, 2018

Long QT syndrome – revealed

Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.

By Bill Snyder
electricity arcing in a heart shape between two exposed wires
March 3, 2017

Mutation raises heart block risk

A newly identified genetic risk factor for heart block after surgery may help guide the course of postoperative care.

By Laura Daniel
May 12, 2014

Normalizing calcium flux to treat atrial fibrillation

A particular anti-arrhythmia drug provides a targeted treatment for certain forms of atrial fibrillation.
By Leigh MacMillan
February 10, 2014

Keeping the beat after heart surgery

Variation in the gene for the beta-1 adrenergic receptor increases the risk that a patient will have an abnormal heart rhythm after cardiac surgery.
By Leigh MacMillan
June 21, 2013

Rhythm response tied to gene variant

A genetic variant that increases risk for atrial fibrillation also impacts the response to a common therapy for the heart rhythm disorder.
By Leigh MacMillan
February 7, 2013

Study tracks genes involved in heart rhythm disorders

A team led by Vanderbilt University investigators has discovered two new genes — both coding for the signaling protein calmodulin — associated with severe early-onset disorders of heart rhythm.
By Leigh MacMillan