Journal of Clinical Investigation

April 18, 2017

Vanderbilt-led study shows high-salt diet decreases thirst, increases hunger

Salted peanuts make you thirsty so you drink more: that’s bartender wisdom. While that may be true in the short-term, within 24 hours increasing salt consumption actually makes you less thirsty because your body starts to conserve and produce water.

By Bill Snyder
firefighters battle a wildfire
October 13, 2016

EGF receptor found to regulate macrophage inflammation in gut

Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract.

By Bill Snyder
child sick to his stomach
April 28, 2016

Study sheds light on link between autism, GI issues

Researchers at Columbia and Vanderbilt universities have made an important discovery in mice that has implications for understanding the gastrointestinal (GI) problems experienced by some children with autism.

By Bill Snyder
January 27, 2016

Study identifies new culprit in lung cancer development

A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung cancer, Vanderbilt University investigators have discovered.

By Leigh MacMillan
October 22, 2015

Study sheds light on side effects of COX-2 drugs

A team of Vanderbilt University Medical Center scientists are closer to understanding why COX-2 inhibitors — drugs that relieve arthritis pain and inflammation without the gastrointestinal side effects of other painkillers — cause heart problems in some patients.

Now

By Bill Snyder
August 13, 2015

VUMC study shifts thinking on how bone fractures heal

New findings show that fibrin, a protein that was thought to play a key role in fracture healing, is not required, shifting understanding of how fractures heal.

By Leigh MacMillan
July 23, 2015

Study explores protein’s role in inflammation-associated cancer

An antioxidant protein may protect against colon cancer that develops in patients with inflammatory bowel disease, suggesting new strategies for reducing colon cancer risk in these patients.
By Leigh MacMillan
June 11, 2015

Study: Why one kidney can work as well as two

Vanderbilt University researchers have come closer to solving a mystery that has puzzled scientists for more than a century: after the loss of one kidney, what causes the growth of the remaining kidney to take up the slack?
By Bill Snyder
May 21, 2015

‘Redesigned’ antibodies may control HIV: study

With the help of a computer program called “Rosetta,” researchers at Vanderbilt University have “redesigned” an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency virus (HIV) than can any known natural antibody.
By Bill Snyder
April 30, 2015

Team tracks how kidney responds to blood pressure meds

Changes in the kidney can limit the blood pressure-lowering effects of thiazide diuretics, a new study reports.
By Leigh MacMillan
April 2, 2015

Gene variant, environment can boost RSV severity

A particular genetic mutation combined with an urban environment increases the risk of severe disease in children infected with respiratory syncytial virus (RSV), an international team of investigators has found.
By Leigh MacMillan
February 12, 2015

VU study explores inflammation, hypertension link

The evidence is increasing: the immune system and inflammation are key contributors to high blood pressure.
By Bill Snyder
November 20, 2014

Gene mutation linked to breast cancer therapy resistance

A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy.
By VUMC News and Communications