Probing the tumor microenvironment

Vanderbilt researchers used single-cell sequencing, imaging, and computational approaches to characterize the colonic tumor microenvironment, providing important insights to the components that play roles in colorectal tumor pathogenesis.

Prostate cancer microenvironment

Distinct cancer-associated fibroblasts in the prostate tumor microenvironment may influence tumor progression and could point to new therapeutic targets.

‘Stretched’ cells promote cancer

Mechanical stress appears to be a critical factor in activating normal tissue-associated fibroblasts to generate cancer-associated fibroblasts.

Immune cell activity and melanoma

The activity of a certain factor in immune cells is essential for an anti-tumor response, emphasizing the need to consider the effects of anti-cancer therapies on immune cells.

Growth factor blockade targets breast tumors

Inhibition of BMP growth factor signaling reduces breast tumor burden and metastasis.

Proteins guard against cancer spread

Targeting immune system proteins may keep prostate cancer from spreading to bone.