NIH

Biochemistry investigators at Vanderbilt have discovered a new DNA repair mechanism that prevents gene mutations during DNA replication.

An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer.

Understanding how a bacterial protein that influences the risk of stomach cancer is produced could guide new strategies for treatment.

Larry Marnett and colleagues have explored the role of two enzymes in metabolizing molecules associated with cell proliferation, inflammatory processes and neurological diseases.

Danny Winder and colleagues demonstrate an interaction between two signaling pathways — and its impact on the activity of neurons that respond to stress.

Matthew Tyska and colleagues have found that an adhesion protein plays a key role in building the intestinal brush border that is essential for absorbing nutrients.

Vanderbilt University Medical Center’s David Zealear, PhD, has received a $3.6 million grant from the National Institutes of Health (NIH) for a clinical trial to study the effectiveness of bilateral laryngeal pacing in treating patients with a bilaterally paralyzed larynx.