NIH

Potential mechanism for myeloma drug’s variable toxicity

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.

Target cell entry to halt Chikungunya virus

Understanding how chikungunya virus binds to and enters cells offers a new target for antiviral medications.

Increased cell permeability may protect from colitis

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation.

New view of neurotransmitter transport

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders.

Nutrient-absorbing surface’s assembly revealed: study

Vanderbilt University researchers have discovered how intestinal cells build the “brush border” — a specialized surface structure that is critical for absorbing nutrients and defending against pathogens.

Channel drug restores glucose balance

A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis.

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