NIMH

Genetics and chronic pain

Polygenic risk scores — scores that reflect the influence of common genetic variants — could be used to predict the likelihood of developing chronic overlapping pain conditions and guide biomarker and targeted prevention efforts.

Sex counts in the brain as seasons change

Photoperiod, or length of day, has sex-specific impacts on dopamine dynamics in the brain, offering insights into sex differences in neuropsychiatric disorders, Vanderbilt researchers report.

Early effects of Huntington disease

Impairments in brain executive function happen earlier than motor symptoms in people with the gene mutation that causes Huntington disease, suggesting younger ages and cognitive symptoms be considered for any future clinical trials.

Researchers develop framework for multiancestry genomic studies

Vanderbilt researchers have developed a framework for the analysis of multiancestry, large-scale genomic studies across multiple biobanks.

Suicide notes

Natural language processing of notes in electronic health records can identify suicidal behavior and could be used to directly improve real-time risk prediction algorithms.

Maria Hadjifrangiskou, PhD, Connor Beebout, PhD, and colleagues are studying why the bacterium E. coli is so tenacious.

Study describes how E. coli co-opts cells, causes recurrent UTIs

Researchers at Vanderbilt University Medical Center have discovered why the uropathogenic bacterium E. coli, the leading cause of urinary tract infections, is so tenacious; their findings could lead to new ways to prevent recurrent UTIs.

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