P450

January 10, 2023

Anti-nausea drug response in children

Genetic variation in a metabolic enzyme was not associated with response to the anti-nausea drug odansetron in children, Vanderbilt researchers report.

By Leigh MacMillan
May 19, 2022

A clue to an adverse drug event in children

Considering metabolic (CYP2D6) enzyme activity score and patient age may aid in determining an individual’s risk for an adverse event with administration of the anti-arrhythmic drug propafenone.

By Joshua Baker
May 9, 2022

Gene variants and transplant drug dose

Genotyping multiple enzymes that metabolize the immunosuppressive drug tacrolimus — common used for lung transplant recipients — is important for correct dosing of the drug, Vanderbilt researchers found.

By Leigh MacMillan
April 5, 2021

Codeine metabolizer status in clinical practice

Vanderbilt researchers have developed a response score using genetic and clinical information to aid prescribing of the widely used pain medication codeine.

By Leigh MacMillan
June 12, 2019

Steroid binding to metabolic enzyme

Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.

By Bill Snyder
July 25, 2017

Altered metabolism and disease

Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

By VUMC News and Communications
June 12, 2013

Antacids: risky for premature babies

Antacids that block a certain enzyme pose a risk for a common cardiac problem in premature infants.
By Leigh MacMillan
October 4, 2012

An orphan enzyme’s purpose

“Orphan” enzyme may play role in cancer growth, new research suggests.
By VUMC News and Communications