pharmacogenomics

January 10, 2023

Anti-nausea drug response in children

Genetic variation in a metabolic enzyme was not associated with response to the anti-nausea drug odansetron in children, Vanderbilt researchers report.

By Leigh MacMillan
September 2, 2021

Study shows gene-drug interactions are common

When a drug or combination of drugs causes different responses in different people, genetic variation is often at play. Pharmacogenomics, through discovery of genetic risk and use of clinical genotyping, aims to reduce trial-and-error approaches to drug prescribing.

By Paul Govern
April 5, 2021

Codeine metabolizer status in clinical practice

Vanderbilt researchers have developed a response score using genetic and clinical information to aid prescribing of the widely used pain medication codeine.

By Leigh MacMillan
Medical laboratory scientist Gladys Garrison, MT, MS, loads reagents to prepare DNA samples for analysis in the VUMC Molecular Diagnostics Lab.
April 30, 2020

PREDICT program expands, opens new Genomics Clinic

A new clinic opening at Vanderbilt University Medical Center will help doctors and patients choose the best drugs for their medical conditions based on the patients’ unique genetic makeup.

By Bill Snyder
September 23, 2019

Tailoring treatment for heart defect

By defining the clinical and genetic factors that predict treatment response, Vanderbilt investigators aim to personalize therapy for a common heart complication in preterm infants.

By Leigh MacMillan
October 1, 2015

Collaboration seeks to develop new therapies for bone, other diseases

La Jolla Pharmaceutical Co. and Vanderbilt University have signed a research and license agreement covering Vanderbilt’s research program and intellectual property rights related to compounds that block bone morphogenetic protein (BMP) type-I receptors. The compounds have therapeutic potential in a broad range of diseases, including rare genetic disorders.

By Leigh MacMillan
July 9, 2015

VUMC lands major pharmacogenomics grant

Vanderbilt University Medical Center has received a five-year, $12.8 million grant from the federal government to develop better ways to predict how patients will respond to the drugs they’re given.
By Bill Snyder
April 23, 2015

Lecture explores efforts to move pharmacogenetics into the clinic

Preemptive genotyping: It sounds like a surprise attack, and it is.
By Bill Snyder
April 23, 2015

Day of events to explore personalized medicine

Vanderbilt faculty and staff are invited to attend Personalized Medicine Day on Friday, May 1, 8 a.m. to 4 p.m. at the Vanderbilt University Student Life Center.
By Paul Govern
June 12, 2014

Roden named to NIH’s genomics advisory council

Dan Roden, M.D., assistant vice chancellor for Personalized Medicine, has been appointed to the National Advisory Council for Human Genome Research of the National Institutes of Health (NIH).
By Bill Snyder
October 24, 2013

Eskind project seeks to demystify genotyping information for patients

With the aid of a two-year, $487,000 National Leadership Grant from the Institute of Museum and Library Services (IMLS), a Vanderbilt research team will develop a reusable model to promote better patient engagement with the health care team through delivery of consumer-friendly pharmacogenetic information.
By Paul Govern
October 17, 2013

Pharmacogenomic testing costs studied

A research team led by Josh Peterson, M.D., MPH, assistant professor of Biomedical Informatics and Medicine, and John Graves, Ph.D., assistant professor of Preventive Medicine, will study the cost-effectiveness of testing patients’ risk of adverse gene-drug interactions.
By Paul Govern