Research

Contributors to the COVID-19 microbiome study include (front row, from left) Julie Bastarache, MD, Meghan Shilts, MS, MHS, (middle row, from left) Jodell Jackson, PhD, Suman Das, PhD, Angela Jones, MS, (back row, from left) Jonathan Schmitz, PhD, MD, Simon Mallal, MBBS, and Jordan Best, PhD.
March 11, 2021

‘Friendly’ bacteria may impact COVID severity

The U.S. Centers for Disease Control and Prevention (CDC) has awarded Vanderbilt University Medical Center a two-year, $3.7-million contract to determine genetic and bacterial factors that may increase the risk for severe illness and death from COVID-19.

By Bill Snyder
March 11, 2021

Electronic health record study discovers novel hormone deficiency

A novel hormone deficiency may exist in humans, Vanderbilt investigators have discovered. In an analysis of two decades worth of electronic health records, the researchers found that some patients have unexpectedly low levels of natriuretic peptide hormone in clinical situations that should cause high levels of the hormone.

By Leigh MacMillan
Danielle Buchanan, BS, right, and Daniel Claassen, MD, MS, are studying the relationship between clinical research coordinators principal investigators. (photo by Donn Jones)
March 8, 2021

Survey identifies factors in reducing clinical research coordinator turnover

Strong, collaborative relationships with principal investigators are a key factor of longevity in clinical research coordinator positions — an essential, but increasingly transient job in executing treatment-advancing clinical trials, Vanderbilt University Medical Center researchers found.

By Holly Fletcher
March 4, 2021

Monoclonal antibody “cocktail” blocks COVID-19 variants: study

A monoclonal antibody “cocktail” developed at Vanderbilt University Medical Center to neutralize the COVID-19 virus is effective against all known strains, or variants, of the virus, according to a report published today in the journal Nature Medicine.

By Bill Snyder
March 4, 2021

Biostatistician DeMets set for next Discovery Lecture

David DeMets, PhD, known for his work on statistical methods to monitor interim clinical trial data for early evidence of benefit or harm, will deliver the next web-based Discovery Lecture.

By Leigh MacMillan
March 4, 2021

Chikungunya antibody identified at VUMC moves forward

Evotec, a drug company headquartered in Hamburg, Germany, has begun a phase 1 clinical trial of a monoclonal antibody against the chikungunya virus that was identified at Vanderbilt University Medical Center.

By Bill Snyder
February 25, 2021

Females with autism reach puberty earlier: study

Blythe Corbett, PhD, professor of Psychiatry and Behavioral Sciences and investigator with the Vanderbilt Kennedy Center, recently led a study which found that on average, females with autism spectrum disorder (ASD) experienced the onset of puberty 9.5 months earlier than their peers.
By Emily Stembridge
February 25, 2021

Case Western’s Jain to discuss age-related disorders at next Discovery Lecture

Mukesh Jain, MD, vice dean for Academic Affairs and Medical Sciences and professor of Medicine at Case Western Reserve University, will discuss the discovery of aging-related disease genes and pathways during the next web-based Discovery Lecture.
By Leigh MacMillan
February 11, 2021

Vanderbilt, Zambia researchers find delirium in hospitalized patients linked to mortality, disability in Sub-Saharan Africa

Delirium, a form of acute brain dysfunction, is widespread in critically ill patients in lower resourced hospitals, and the duration of delirium predicted both mortality and disability at six months after discharge, according to a study published in PLOS ONE.
By Holly Fletcher
February 11, 2021

Grant supports speedy sorting of health records by phenotype

Wei-Qi Wei, MD, PhD, assistant professor of Biomedical Informatics and scientific director of the Precision Phenotyping Core at the Center for Precision Medicine, has been awarded a four-year, $1.7 million grant from the National Institutes of Health (grant GM139891) to continue
By Paul Govern
February 11, 2021

Study will delve into EHR for signs of suicidality

Retrieval of clearer, more complete information from the EHR could go a long way toward improving predictive models of who will next be at risk of suicide, thereby improving care for patients with suicidal thoughts and behaviors.
By Paul Govern
February 5, 2021

Convalescent plasma improved survival in COVID-19 patients with blood cancers

Treatment with convalescent plasma vastly improved the survival rate of patients hospitalized for COVID-19 who also had hematologic malignances that compromise the immune system, according to new data released by the COVID-19 and Cancer Consortium (CCC19).
By Tom Wilemon
February 2, 2021

Study finds recommended ICU sedatives equally safe, effective

Sedative medications used in intensive care are associated with increased delirium, which is in turn connected with higher medical costs and greater risk of death and ICU-related dementia.
By Paul Govern
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