Research

June 29, 2023

Selenium signal found in colorectal cancer: study

An antioxidant transporter of the trace mineral selenium that protects against inflammatory bowel disease has the opposite effect in colorectal cancer, where it promotes tumor growth, researchers at Vanderbilt University Medical Center have reported.

By Bill Snyder
June 29, 2023

Persistent inflammatory state found in half of pediatric sepsis deaths: study

New research shows that about half of pediatric patients who died of sepsis over the past 20 years at Vanderbilt University Medical Center had evidence of an inflammatory state called persistent inflammation, immunosuppression and catabolism syndrome.

By Leigh MacMillan
June 29, 2023

Ayaka Sugiura, PhD, and Camille Wang receive P.E.O. Scholar Awards

Ayaka Sugiura, PhD, and Camille Wang, aspiring physician-scientists in the Medical Scientist Training Program at Vanderbilt, are among this year’s recipients of highly competitive P.E.O. Scholar Awards.

By Bill Snyder
June 27, 2023

Rare disorder sheds light on dysbindin function

A case study of a rare disorder uncovers roles for the protein dysbindin in the adaptive immune response and suggests that mutations may underlie some cases of very early onset inflammatory bowel disease.

By Sarah E. Glass
June 26, 2023

Magnesium deficiency and blood pressure

Dietary magnesium depletion in a mouse model activated inflammatory pathways and molecules that promote hypertension, suggesting that increased magnesium consumption may be beneficial for reducing the prevalence of hypertension.

By Leigh MacMillan
June 22, 2023

Pathways to a healthy liver

Hepatic stellate cells maintain liver mass and function; the signaling factors they use could be exploited therapeutically to promote liver regeneration and inhibit cancerous proliferation, Vanderbilt researchers suggest.

By Bill Snyder
June 22, 2023

Mosaicism and genetic disease

Genetic mosaicism — when the body’s cells do not all have the same genetic makeup — could generate variants previously thought to be spontaneous in genetic disease, and detecting parental mosaicism could clarify recurrence risk for future children.
By Leigh MacMillan
June 22, 2023

VUMC, Oxford team develops ‘blueprint’ to block lethal virus

Researchers at Vanderbilt University Medical Center and the University of Oxford have determined how a human monoclonal antibody isolated at Vanderbilt in 2021 can prevent infection by the potentially lethal Sin Nombre virus.
By Bill Snyder
June 14, 2023

NIH grant boosts international TB research consortium

A new grant will help support Vanderbilt's RePORT Brazil, one of an international consortium’s six regional tuberculosis research programs.
By Paul Govern
June 13, 2023

Maternal diet influences postnatal diabetes risk

Studies in a primate animal model suggest that islet hyperfunction — which in humans is associated with increased fat mass and Type 2 diabetes — is programmed in offspring by a maternal Western-style diet during pregnancy.
By Bill Snyder
June 12, 2023

Images predict functional decline

MRI brain scans at baseline for study participants 60 and older — who were free of clinical dementia at study entry — predicted a decline in independent function five years later.
By Paul Govern
June 8, 2023

Targeting calcium handling in A-fib

The drug ent-verticilide reduced A-fib incidence and duration in an animal model, suggesting it may be a viable therapeutic option.
By Leigh MacMillan
June 8, 2023

An image of cancer treatment response

An MRI method developed by Vanderbilt researchers uses imaging data to derive cell size and could be added to clinical practice for better monitoring of breast cancer treatment response.
By Sarah E. Glass
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