TGF-beta

October 10, 2022

Opening a window to glaucoma

A metalloprotease enzyme plays an important role in retinal ganglion cell development, Vanderbilt researchers discovered; studying it and other family members may lead to the identification of novel targets for treating glaucoma.

By Bill Snyder
March 4, 2021

Probiotic protection

A probiotic factor given early in life to mice prevented intestinal inflammation in adulthood, providing a rationale for probiotic intervention in individuals at high risk of developing inflammatory bowel disease.

By Anivarya Kumar
June 4, 2020

Potential new cancer target

Vanderbilt researchers have discovered the involvement of a certain type of adenosine receptor in mediating signaling that supports tumor growth and metastasis.

By Bill Snyder
July 2, 2018

SMAD4 clue to colon cancer

Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.

By Bill Snyder
October 19, 2017

Symposium honors Moses’ storied cancer research career

Members of the Vanderbilt University Medical Center (VUMC) community and others whose lives and careers have been influenced by legendary cancer investigator, educator and administrator Harold (Hal) Moses, M.D., have endowed the Linda and Harold L. Moses, M.D. Career Development Fund.

By VUMC News and Communications
Illustration of human intestinal tract
January 19, 2017

Colorectal cancer clues

Although cancers arising from different areas of the large intestine are heterogeneous, they appear to use similar important tumorigenic pathways.

By Leigh MacMillan
April 16, 2015

Surprising finding in the kidney

TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling.
By VUMC News and Communications
January 8, 2015

Enzyme affects tumor metastasis

A protein that degrades the “matrix” between cells participates in the development of lung metastases from primary breast cancer in mouse models and may be a good target for breast cancer treatment.
By VUMC News and Communications
November 12, 2014

New insight on oral cancer culprits

A new mouse model offers insight into the signaling pathways that control oral cancers – and a platform for testing anticancer therapeutics.
By Elizabeth Conrad
July 10, 2014

Molecular ‘chat’ holds kidney fibrosis clues

A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process.
By Leigh MacMillan
December 26, 2012

Preventing hardened heart valves

Blocking a serotonin receptor may provide a novel therapy for heart valve disease.
By Leigh MacMillan
July 24, 2012

Proteins guard against cancer spread

Targeting immune system proteins may keep prostate cancer from spreading to bone.
By VUMC News and Communications
March 23, 2012

Smoking stokes cells’ cancer capacity

Cellular pathways altered by chronic exposure to cigarette smoke may reveal new biomarkers to assess smoking-induced lung cancer risk.
By VUMC News and Communications
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