tuberous sclerosis complex

brain and lightning

Astrocytes and epilepsy

A protein with important functions in astrocytes — star-shaped brain support cells — may alter neuronal excitability and contribute to seizure activity, Vanderbilt researchers report.

Neuronal subtypes in genetic disorder

Inhibitory neurons that connect and regulate signaling in the brain (interneurons) may contribute to epilepsy and autism in patients with tuberous sclerosis complex.

Treatment window for genetic disorder

Treatment with a drug used to prevent organ rejection partially reverses the course of tuberous sclerosis, research in mice suggests.