tumor

Vanderbilt nanodrug may be a paradigm shift for cancer

A multidisciplinary research team at Vanderbilt University and Vanderbilt University Medical Center has discovered a new way to kill a tumor by disrupting its acidic “microenvironment” without harming normal tissue.

Probing the tumor microenvironment

Vanderbilt researchers used single-cell sequencing, imaging, and computational approaches to characterize the colonic tumor microenvironment, providing important insights to the components that play roles in colorectal tumor pathogenesis.

Probing innate immunity

Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.

close up of blood vessels

VICC study sheds new light on Von Hippel-Lindau syndrome

Investigators at Vanderbilt-Ingram Cancer Center (VICC) and the Virginia Tech Carilion Research Institute (VTCRI) have revealed a gene mutation’s role in Von Hippel-Lindau syndrome, a genetically inherited disease which causes tumor growth in several organs.

Oxidative stress in tumors

Vanderbilt investigators have developed a new method for measuring oxidative stress in human tumors, which provides insight into cancer development.

Origins of neuroblastoma

Vanderbilt researchers are exploring how neuroblastoma tumors begin and progress, knowledge that could provide new treatments for this pediatric cancer.

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