Annals of Neurology (journal)

Stephen Purcell
June 5, 2024

It’s been 16 years since sweet-spot brain stimulation slowed Parkinson’s progression for Hermitage man

In 2008 at VUMC there were a group of doctors trying something unheard of on a handful of patients who signed up for their study. Half would receive deep brain stimulation (DBS) surgery in attempt to slow the progression of their early-stage Parkinson’s disease, and the others would not.

By Craig Boerner
September 7, 2023

Low-flow cerebrospinal fluid in Huntington’s disease: study

Vanderbilt researchers found reduced net flow of cerebrospinal fluid in Huntington’s disease, which could contribute to mutant protein retention and altered responsiveness to medications delivered via the spinal cord.

By Paul Govern
photo of David Charles and Mallory Hacker
June 7, 2023

Deep brain sweet spot might be key to halt Parkinson’s

A sweet spot in the deep brain with direct lines of communication to motor regions far out on the cerebral cortex might hold a key to halting the progression of early-stage Parkinson’s disease.

By Paul Govern
April 11, 2014

Myelin junctions key to conduction

A protein in the myelin coating on nerves helps form a “seal” that enables effective nerve conduction; loss of the protein causes inherited neuropathies.

By Leigh MacMillan