arrhythmia (irregular heartbeat)

September 27, 2024

Distant relatedness in biobanks harnessed to identify undiagnosed genetic disease

VUMC researchers have developed a genetic method that clusters distantly related people to find rare variants that were present in a common ancestor.

By Leigh MacMillan
Atrial Fibrillation Precision Research Program clinic team members arrange genetic testing for patients with AFib. (photo by Erin O. Smith)
August 7, 2024

Program arranges genetic testing for AFib patients who may be at risk for inherited cardiomyopathy or arrhythmia syndromes

Without treatment, younger patients may develop other serious cardiac disorders such as heart failure or life-threatening ventricular arrhythmias.

By Matt Batcheldor
June 8, 2023

Targeting calcium handling in A-fib

The drug ent-verticilide reduced A-fib incidence and duration in an animal model, suggesting it may be a viable therapeutic option.

By Leigh MacMillan
July 7, 2022

Preempting sudden cardiac death

A technique to characterize all variants in genes associated with arrhythmia could improve the ability to identify and preemptively treat individuals at risk for sudden cardiac death.

By Bill Snyder
May 19, 2022

A clue to an adverse drug event in children

Considering metabolic (CYP2D6) enzyme activity score and patient age may aid in determining an individual’s risk for an adverse event with administration of the anti-arrhythmic drug propafenone.

By Joshua Baker
Studies by Andrew Glazer, PhD, Giovanni Davogustto, MD, and colleagues found that genetic testing with information from electronic health records can reveal undiagnosed heart rhythm disorders.
April 28, 2022

Studies combine genetic testing, electronic health records to find undiagnosed diseases

Combining genetic testing with information from electronic health records revealed undiagnosed heart rhythm disorders and new conditions associated with inherited cancer gene mutations.

By Leigh MacMillan
February 24, 2022

VUMC researchers find clue to drug-induced arrhythmias

Vanderbilt University Medical Center researchers have made a fundamental discovery about how the heart compensates for genetic variations that otherwise could trigger abnormal and potentially fatal heart rhythms.
By Bill Snyder
October 7, 2021

Study finds genetic testing useful for young AFib patients

Vanderbilt research shows that genetic testing in patients with early-onset atrial fibrillation can identify variants associated with more serious cardiomyopathy and arrhythmia syndromes that may otherwise remain undiagnosed.
By Matt Batcheldor
April 15, 2021

Arrhythmia culprit: supertrafficking ion channel

Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities.
By Leigh MacMillan
March 11, 2021

Genotype looms large in risk for post-op arrhythmia

Postoperative atrial fibrillation (PoAF), a form of arrhythmia, complicates 20-40% of cardiac surgical procedures and 10–20% of non-cardiac thoracic operations, cropping up two to four days after surgery to pose risk of stroke, heart attack, mortality, longer hospital stays and greater cost.
By Paul Govern
June 12, 2020

Robotic technology speeds arrhythmia gene classification

Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions.
By Leigh MacMillan
June 26, 2019

VUMC receives portion of $14 million AHA award to study arrhythmias and sudden cardiac arrest

VUMC receives more than $3.7 million from the American Heart Association to study cardiac arrhythmia and sudden cardiac arrest
By Matt Batcheldor
August 16, 2018

Risk factors for faulty rhythms

Risk factors for arrhythmias after heart surgery in infants include medications, infant age and higher surgical complexity, but not two genetic variants examined by Vanderbilt researchers.
By Leigh MacMillan
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