atherosclerosis

August 13, 2024

$3.4 million research grant targets risk of heart attack, stroke

Making innovative use of observational data, researchers hope to gain new understanding of patient risk and identify existing drugs to lower risk.

By Paul Govern
April 30, 2024

Atherosclerosis is a tumor-like disease: study

An anticancer drug blunted atherosclerosis progression — and even made plaques shrink — in a mouse model of the disease, opening new opportunities for preventing and treating this leading cause of death.

By Leigh MacMillan
The study could suggest ways to promote the transport of phospholipids and cholesterol out of macrophages, immune system cells that play key roles in all stages of atherosclerosis development.
March 23, 2023

Reminders for clinicians improve prescribing for high cholesterol

A Vanderbilt study found that automated targeted reminders for clinicians helped increase prescribing of high intensity statins for patients with various atherosclerotic cardiovascular disease diagnoses, including coronary or peripheral artery disease and ischemic stroke.

By Paul Govern
The study found that chronically disrupted sleep and highly variable sleep durations night after night may increase the risk for atherosclerosis.
February 15, 2023

Study finds chronically disrupted sleep may increase risk for heart disease

Vanderbilt research found that sleep irregularity — chronically disrupted sleep and highly variable sleep durations night after night — may increase the risk for atherosclerosis.

By Bill Snyder
The study could suggest ways to promote the transport of phospholipids and cholesterol out of macrophages, immune system cells that play key roles in all stages of atherosclerosis development.
January 19, 2023

Study points to new ways to prevent, treat heart disease

Vanderbilt researchers have confirmed the existence of an alternative pathway to atherosclerosis, a finding that may lead to new ways to prevent and treat cardiovascular disease.

By Bill Snyder
The study could suggest ways to promote the transport of phospholipids and cholesterol out of macrophages, immune system cells that play key roles in all stages of atherosclerosis development.
September 15, 2022

Study suggests new mechanism for lipid transporter

A new model suggests that a protein involved in the generation of high-density lipoprotein (HDL) works differently than previously thought.

By Leigh MacMillan
August 25, 2022

Rheumatoid arthritis and heart disease: a common path

An increase in certain antibodies in patients with rheumatoid arthritis can serve as a predictive biomarker for cardiovascular disease, Vanderbilt researchers have discovered.
By Bill Snyder
March 29, 2022

There’s no slowing arterial stiffening

Over 10 years, multiple healthy behaviors did not slow the progression of arterial stiffness, a risk factor for coronary artery disease, hypertension, stroke, atrial fibrillation and heart failure.
By Paul Govern
August 19, 2021

Potential protection from atherosclerosis

Vanderbilt researchers have discovered a potential way to reduce atherosclerosis: blocking the modification of an HDL-associated enzyme by reactive molecules called isolevuglandins.
By Bill Snyder
July 8, 2021

Nature’s “recycler” could reduce heart disease risk: study

Researchers at Vanderbilt University Medical Center have identified potential new targets for the prevention of atherosclerosis through the enhancement of autophagy, a natural process for recycling damaged cellular material.
By Bill Snyder
January 21, 2021

NIH grant bolsters research on heart disease, cholesterol

Thanks to major funding from the National Institutes of Health (NIH), researchers at Vanderbilt University Medical Center have made major inroads in understanding how high-density lipoprotein (HDL), commonly known as good cholesterol, in some cases may actually contribute to the development of atherosclerosis.
By Bill Snyder
August 20, 2020

‘Scavenger’ molecule may point to new atherosclerosis treatment

A small-molecule “scavenger” that reduces inflammation and formation of atherosclerotic plaque in blood vessels in mice potentially could lead to a new approach for treating atherosclerosis in humans, according to researchers at Vanderbilt University Medical Center.
By Bill Snyder
July 27, 2020

Soy food, metabolism and the microbiome

Consumption of soy foods may shape the microbiome and protect against hypertension only in individuals with soy-responsive microbiota, Vanderbilt researchers have discovered.
By Sarah E. Glass
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