Department of Anesthesiology

Large study finds higher burden of acute brain dysfunction for COVID-19 ICU patients

COVID-19 patients admitted to intensive care in the early months of the pandemic were subject to a significantly higher burden of delirium and coma than is typically found in patients with acute respiratory failure. Choice of sedative medications and curbs on family visitation played a role in increasing acute brain dysfunction for these patients.

VA adopts enhanced recovery for total knee, total hip patients

For patients receiving total knee or total hip replacements at the Nashville VA Medical Center, the use of opioids for inpatient pain management and the total time patients spent in the hospital were both greatly reduced following the January 2016 adoption of sweeping quality improvement measures.

Polymer protection for heart muscle

Vanderbilt researchers demonstrate that the polymer P188 has promise as a therapy to prevent reperfusion injury — the cellular damage that occurs when blood flow returns after an ischemic event like a heart attack.

The Liver Transplant Anesthesia team includes, from left, Clayne Benson, MD, Kevin Furman, MD, Philip Leisy, MD, and Kara Siegrist, MD.

New approach helps conserve blood products for liver transplant patients

Liver transplants have traditionally required a high volume of transfusions of blood products, which comes with several downsides. The products are costly to patients — as high as $15,000 on top of the expense of a transplant. And they are sometimes not well accepted in patients because they degrade over time and are derived from multiple patients.

Histamine circuits in brain reward center

Histamine — commonly associated with allergies — also has a signaling role in the brain’s reward center and may offer a novel target for treating addiction.

NIAAA director Koob set for Nov. 5 virtual Discovery Lecture

The Discovery Lecture Series launches this fall with a webinar format, the first featuring George Koob, PhD, director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health.

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