Division of Clinical Pharmacology

March 17, 2025

Where are all the Alzheimer’s drugs?

A new study will use innovative methods developed at VUMC to look for drugs already approved for other uses that could potentially be repurposed to treat Alzheimer’s.

By Paul Govern
January 23, 2025

Elite society honors two VUMC physician-scientists

The Young Physician-Scientist Award recognizes “notable achievements” by researchers who are within five years of their first faculty appointment.

By Bill Snyder
October 21, 2024

Clue to salt-sensitive blood pressure found

Despite the well-established link between high salt intake and cardiovascular disease and stroke, the mechanism of SSBP is poorly understood, and it remains an untreatable cardiovascular risk with no widely available diagnostic tool.

By Bill Snyder
September 27, 2024

Distant relatedness in biobanks harnessed to identify undiagnosed genetic disease

VUMC researchers have developed a genetic method that clusters distantly related people to find rare variants that were present in a common ancestor.

By Leigh MacMillan
September 9, 2024

Peptide discovery could advance treatment of high blood pressure

VUMC researchers found that peptides modified by highly reactive compounds called isolevuglandins activated T cells and promoted hypertension in mice. Their first-ever isolation of such peptides is a step toward potentially intervening in this pathologic process.

By Bill Snyder
August 13, 2024

$3.4 million research grant targets risk of heart attack, stroke

Making innovative use of observational data, researchers hope to gain new understanding of patient risk and identify existing drugs to lower risk.

By Paul Govern
June 3, 2024

Genetic variation associated with low white blood cell count impacts clinical decisions

People whose white blood cell levels are near the edge of the “healthy” reference range will hit a clinical decision point that has consequences such as diagnostic procedures and altered treatments.
By Leigh MacMillan
March 14, 2024

Pain medication. Cosmetics. Cleaning supplies. Tennessee Poison Center’s message: lock them away.

TPC’s help hotline —1-800-222-1222 — is staffed by nurses, pharmacists, physicians and board-certified medical toxicologists who are specially trained to assist callers.
By Jessica Pasley
March 7, 2024

Study details metabolism of biomarkers for oxidative stress

Factors other than oxidative stress can modify the levels of biomarkers called isoprostanes that are commonly used in both experimental and clinical research, suggesting that additional standards need to be developed.
By Leigh MacMillan
February 19, 2024

VUMC part of major step to achieving precision medicine

An analysis of genomic data from nearly 250,000 participants in the National Institutes of Health’s All of Us Research Program has identified more than 275 million previously unreported genetic variations, nearly 4 million of which have potential health consequences.
By Bill Snyder
February 1, 2024

A biomarker for early Type 2 diabetes

Genetic analyses suggest that branched chain amino acids may be a sensitive biomarker of early or subclinical Type 2 diabetes and could be used to identify risk and implement preventive measures.
By Bill Snyder
October 31, 2023

Polygenic “scores” may improve cancer screening

Accounting for genetic variability in biomarkers not associated with cancer risk could avoid unnecessary diagnostic procedures, Vanderbilt researchers found.
By Bill Snyder
October 25, 2023

Study to explore link between salt taste sensitivity and salt intake, hypertension and genetic variations in individuals of African descent

A new study will explore the link between salt taste sensitivity and salt intake, blood pressure, hypertension, and genetic variations in individuals of African descent.
By VUMC News and Communications
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