Neurology (journal)

July 15, 2021

Arterial stiffening linked to Alzheimer’s disease

A research team from Vanderbilt University Medical Center reports in Neurology that greater stiffening of the aorta, the main artery in the human body, is associated in older adults with increased Alzheimer’s disease (AD) pathology as reflected in a range of neurochemical indicators measured in cerebrospinal fluid.

By Paul Govern
June 3, 2021

VUMC team discovers new genetic disease

Researchers at Vanderbilt University Medical Center have discovered a new genetic disease that causes a severe form of neurogenic orthostatic hypotension, a rapid drop in blood pressure upon standing that can cause fainting.

By Bill Snyder
photo of David Charles and Mallory Hacker
June 30, 2020

Pilot study suggests Parkinson’s disease progression can be slowed

A pair of ultra-thin electrodes surgically implanted deep into the brain might slow the progression of Parkinson’s disease, according to five-year outcomes from a 30-patient randomized clinical trial conducted by investigators at Vanderbilt University Medical Center.

By Paul Govern
June 6, 2019

Treating core Rett syndrome symptoms

A new study published in Neurology reports the drug trofinetide has proven safe and effective in treating core symptoms of Rett syndrome in female children and adolescents.

By Kelsey Herbers
March 21, 2019

Small vessel disease MRI marker linked to worse cognitive health in older adults

Enlarged perivascular spaces, which are commonly seen on brain MRIs in older adults, have important associations with worse cognitive performance, particularly information processing speed and executive function, according to a new study that challenges historical consideration that perivascular spaces are a harmless imaging marker.

By Holly Fletcher
photo of David Charles and Mallory Hacker
June 29, 2018

DBS treatment may slow tremor progression in early-stage Parkinson’s patients

June 29, 2018 – Analysis of data from a clinical trial conducted at Vanderbilt suggests that deep brain stimulation (DBS) administered to patients with very early-stage Parkinson’s disease slowed the progression of rest tremor. The study, published June 29 in Neurology, is significant because it is the first evidence of a treatment that may possibly delay the progression of one of the cardinal features of Parkinson’s disease.

By Tom Wilemon
May 31, 2018

Research reveals underappreciated role of brainstem in epilepsy

New research from Vanderbilt suggests that repeated seizures reduce brainstem connectivity, a possible contributor to unexplained neurocognitive problems in epilepsy patients.
By Tom Wilemon
November 16, 2017

Drug’s effectiveness for neurosarcoidosis studied

A drug commonly prescribed for Crohn’s disease and rheumatoid arthritis is also effective for treating neurosarcoidosis, according to new research led by Vanderbilt neurologists.
By Tom Wilemon
November 8, 2017

Research links heart function to brain’s memory center

Research by a team of Vanderbilt University Medical Center (VUMC) scientists suggests that older people whose hearts pump less blood have blood flow reductions in the temporal lobe regions of the brain, where Alzheimer’s pathology first begins.
By Tom Wilemon
November 10, 2016

Alzheimer’s study establishes way to measure resilience

Vanderbilt researchers have established a new measure of resilience to cognitive impairment in people with asymptomatic Alzheimer’s disease.
By Tom Wilemon
August 13, 2015

Protein ‘clumping’ linked to severe form of genetic epilepsy

Researchers at Vanderbilt University for the first time have demonstrated in a mouse model that aggregation, the “clumping together” of abnormal proteins, can contribute to a severe form of genetic epilepsy.
By Bill Snyder